INVESTIGATION ON HEPATITIS C AND B VIRUS INFECTION IN CARCINOMA OF THE EXTRAHEPATIC BILE DUCT IN CHINA
Abstract
Objective: The incidence of carcinoma of extrahepatic bile duct tends to increase during recent decade in China, but its cause is unclear. This study is to investigate the Hepatitis C virus (HCV) and Hepatitis B virus (HBV) infection in the tissues of carcinoma of extrahepatic bile duct and study their correlation.
Methods: HCV RNA and HBV DNA was detected by in situ polymerase chain reaction (ISPCR) in sections of 51 cases of carcinoma of extrahepatic bile duct and 34 cases of control group.
Results: Of 51 carcinoma of extrahepatic bile duct, HCV RNA was detected in 18 (35.4%), HBV DNA in 8 (15.9%). In 34 cases of control group, HCV RNA was detected in 2 (5.9%), and HBV DNA in 3 (8.8%).
Conclusion:The prevalence of hepatitis C and B viral infection in the tissues of carcinoma of extrahepatic bile duct was significantly higher than in control group. The findings suggest a correlation between HCV, HBV infection and carcinoma of extrahepatic bile duct, inferring HCV and HBV might be involved in the development of carcinoma of extrahepatic bile duct.
Methods: HCV RNA and HBV DNA was detected by in situ polymerase chain reaction (ISPCR) in sections of 51 cases of carcinoma of extrahepatic bile duct and 34 cases of control group.
Results: Of 51 carcinoma of extrahepatic bile duct, HCV RNA was detected in 18 (35.4%), HBV DNA in 8 (15.9%). In 34 cases of control group, HCV RNA was detected in 2 (5.9%), and HBV DNA in 3 (8.8%).
Conclusion:The prevalence of hepatitis C and B viral infection in the tissues of carcinoma of extrahepatic bile duct was significantly higher than in control group. The findings suggest a correlation between HCV, HBV infection and carcinoma of extrahepatic bile duct, inferring HCV and HBV might be involved in the development of carcinoma of extrahepatic bile duct.