Cancer incidence and mortality in China in 2013: an analysis based on urbanization level
With the economic development and changes associated with urbanization, as well as the population growth and aging, the incidence and mortality of cancer keep increasing in China. The National Central Cancer Registry (NCCR) is responsible for collecting population-based cancer registration data from local cancer registries for cancer statistics and publishing cancer registry annual report. The cancer registration data are widely used not only for cancer control and decision making, but also for scientific research. This study was designed based on the latest available population-based data to explore the differences of cancer epidemiology among different urbanization areas in China.
Boron neutron capture therapy for malignant melanoma: first clinical case report in China
A phase I/II clinical trial for treating malignant melanoma by boron neutron capture therapy (BNCT) was designed to evaluate whether the world’s first in-hospital neutron irradiator (IHNI) was qualified for BNCT. In this clinical trial planning to enroll 30 patients, the first case was treated on August 19, 2014. Only grade 2 acute radiation injury was observed during the first four weeks after BNCT and the injury healed after treatment. No late radiation injury was found during the 24-month follow-up. Based on positron emission tomography-computed tomography (PET/CT) scan, pathological analysis and gross examination, the patient showed a complete response to BNCT, indicating that BNCT is a potent therapy against ...
Non-anthracycline-containing docetaxel and cyclophosphamide regimen is associated with sustained worse outcome compared with docetaxel, anthracycline and cyclophosphamide in neoadjuvant treatment of triple negative and HER2-positive breast cancer patients: updated follow-up data from NATT study
In this study, TNBC or HER2-positive breast cancer patients who achieved pCR had a significantly improved EFS and OS than those without pCR. NeOAdjuvant Herceptin (NOAH) study demonstrated that the doubled pCR rate ...
Upregulation of kazrin F by miR-186 suppresses apoptosis but promotes epithelial-mesenchymal transition to contribute to malignancy in human cervical cancer cells
Kazrin acts as a dual regulator of intercellular adhesion and differentiation in keratinocytes and regulates these processes through Rho-dependent and Rho-independent mechanisms. Knockdown of kazrin impairs axial elongation, cell differentiation and epidermal morphogenesis in developing Xenopus tropicalis embryos. We previously identified a new isoform named kazrin F and found it plays an important role in regulating cellular apoptosis by interacting with ARC and Bax. In this study, we first demonstrated that kazrin F is upregulated in human CC tissues and enhances the proliferation