Article Abstract

MUTATION AND ABNORMAL EXPRESSION OF P16 INK4a IN HEPATOCELLULAR CARCINOMA

Authors: Sheng-liang Zhang,Yao-zheng Zhang,Ping Yan,He-li Gao

Abstract

Objective: To investigate the relationship between p16INK4b and primary hepatocellular carcinoma (HCC), especially hepatitis B-related HCC.

Methods: p16INK4b and its protein in HCC were analyzed with PCR-SSCP and the immunohistodaemlstry methods respectively.

Results: The positive incidence of p16INK4b protein expressing in HCC was lower than that of normal liver tissue (P<0.05), and the absence of p16INK4b protein was associated with HCC metastasis (P<0.05). The low frequency of mutation of p16INK4b exonl and exon2 upstream fragment was found in HCC.

Conclusion: Absence of p16INK4b protein in HCC was not associated with HBV-infeetion.

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