Article Abstract

APOPTOTIC THRESHOLD OF ADRIAMYCIN AND CISPLATIN IN HEPATOCELLULAR CARCINOMA

Authors: Xiaodong Sun,Xueyun Zhong,Xing'e Liu,Yunxiau Chen

Abstract

Objective: To investigate the apoptotie threshold of adriamycln (ADM) and cisplatin (CDDP) on hepatocellular carcinoma (HCC).

Methods: Sensitivities of ADM and CDDP on HCC were studied by primary cell culture.

Results: The apoptotie threshold of ADM and CDDP were 1.0μg/ml and 1.5μg/ml respectively (its clinical dosage was 20 rng and 30 mg respectively).

Conclusion: Understanding apoptotic threshold of anticancer drugs may reduce elinieal dosages of anticaneer drugs and reduce the incidence of multidrug resistance (MDR).

Article Options