STUDIES ON THE HISTOLOGICAL CLASSIFICATION OF PROLIFERATIVE DISEASE OF BREAST AND ITS RELATION WITH BREAST CARCINOMA
Abstract
Objective: Proliferative disease of breast (PDB) always exists compositely, it is difficult to be classified during pathologic diagnosis. For probe into the relationship between PDB and breast carcinoma in the cyto-biologic level, a new classification method was studied.
Materials and methods: Specimen slices of 439 PDB in females and 176 breast carcinomas were studied in contrast. The degree of fibroplastie proliferation was taken as the classifying index of the consecutive progress of PDB. Then the PDB eases were divided into three types: the Iobular byperplastic type (LHT), the fibroadenosis type (FAT) and the fibrosclerosis type (FST). Each type was once again separated into simple and compound groups. A part of these slices were stained with monoclonai immunohistochemieal stain to demonstrate the hyperplastic activities of PDB cells as well as the encirclement of perlductal myoepitbelial cells and base membrane.
Results: PCNA express level was increased successively along with the progress of pathologic changes in all the three types of PDB. And especially, it was almost parallel with the cancerous express in FST. ASMA staining showed atrophy and rupture of periductal myoepithelial cells and base membrane in FST and serious untypical hyperplastic PDB cases.
Conclusions: In FST and serious untypical hyperplastic PDB cases, the ductal epithelial cells proliferated vigorously, it is closely related with the growth of carcinomas. The imeomplete encirclement of peridnctal myoepithelial cells and base membrane are also a sort of dangerous factor.
Materials and methods: Specimen slices of 439 PDB in females and 176 breast carcinomas were studied in contrast. The degree of fibroplastie proliferation was taken as the classifying index of the consecutive progress of PDB. Then the PDB eases were divided into three types: the Iobular byperplastic type (LHT), the fibroadenosis type (FAT) and the fibrosclerosis type (FST). Each type was once again separated into simple and compound groups. A part of these slices were stained with monoclonai immunohistochemieal stain to demonstrate the hyperplastic activities of PDB cells as well as the encirclement of perlductal myoepitbelial cells and base membrane.
Results: PCNA express level was increased successively along with the progress of pathologic changes in all the three types of PDB. And especially, it was almost parallel with the cancerous express in FST. ASMA staining showed atrophy and rupture of periductal myoepithelial cells and base membrane in FST and serious untypical hyperplastic PDB cases.
Conclusions: In FST and serious untypical hyperplastic PDB cases, the ductal epithelial cells proliferated vigorously, it is closely related with the growth of carcinomas. The imeomplete encirclement of peridnctal myoepithelial cells and base membrane are also a sort of dangerous factor.