Article Abstract

RELATION OF MALIGNANT TUMOR TO PROSTACYCLIN AND THROMBOXANE

Authors: Yaying Tan,Bin Wang,Fuguang Liu,Lianmei Zhou,Jun Liu

Abstract

The level of 6-keto-PGF and thromboxane B2 (TXB2) in plasma was determined with radioimmunoassay in 58 normal subjects and 92 patients with various cancers (including lung, hepatic, gastric, esophageal and pancreatic carcinoma). The results showed that 6-keto-PGF in plasma was 10.21±2.75 Pg/ml, and TXB2 146.03±37.31 Pg/ml in normal individuals, the ratio of 6-keto-PGF to TXB2 was 0.07; while in cancer patients 6-keto-PGF was 27.5±16.9 Pg/ml and TXB2 315.4±173.4 Pg/ml, the ratio of 6-keto-PGF to TXB2 was 0.08. The values of 6-keto-PGF and TXB2 in plasma of cancer patients were 2.69 folds and 2.16 folds higher than that of the two groups, respectively. The difference between the two groups was statistically significant (P<0.01). It indicates that, the synthesis and release of PGI2 and TXA2 of cancer tissues increases greatly as compared to the normats.

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