Article Abstract

DISTRIBUTION PATTERNS OF EXTRACELLULAR HEPATOCELLULAR CARCINOMA AND THEIR CLINICAL SIGNIFICANCE

Authors: Yuan-gen Fu,Zhi-zhi Huan,Shui-ping Liu,Shao-yian Zheng,Ying-rui Liang,Yan-qin Shen,Rui-ming Zheng,Qiao-shan Li

Abstract

Objective: In order to find out the distribution patterns of extracellular matrix (ECM) in hepatoceilular carcinoma (HCC) and explore the relationshi between distribution patterns and hepatocellular caricnoma malignancy.

Methods: Forty cases of HCC were studied by immunohitochemistry with 5 antibodies of anti-ECM.

Results; Four types of distribution patterns were found: 1. continuous peritrabecular or periacinar type; 2. discontinuous peritrabecular or periacinar type; 3. vascular stroma type; 4. membrane and cytoplasmic type. The former 3 types were correlated closely with the growth pattern, cell differntiation and proliferation of tumor.

Conclusions: ECM were useful marker for valution of malignant degree in HCC.

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