Article Abstract

INHIBITION OF APOPTOSIS BY bcr-abl FUSION GENE IN K562 CELLS

Authors: Chun-hong Wang,Bing-zhong Sun,Yue-chuan Yuan

Abstract

Objective: To investigate the effect of bcr-abl fusion gene on CML cell apoptosis.

Methods: Apoptosis of exvivo cultured K562 cells were observed after exposure to synthetic 18 mer antisense oligodeoxynucleotide complementary to the bcr-abl junction (b3a2).

Results: Apoptosis of K562 cells was significantly increased associated with inhibition of bcr-abl expression.

Conclusion: bcr-abl fusion gene formation due to chromosome translocation may be the major mechanism of CML via inhibition of apoptosis.

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